[PAGID] IFN-gamma

[HOWARD M LEDERMAN]

Mortality is still high for pulmonary aspergillosis in a CGD pt.  I would not rely on anti-fungals alone

Howard
Howard M. Lederman, M.D., Ph.D.
Professor of Pediatrics and Medicine
Division of Pediatric Allergy and Immunology
Johns Hopkins Hospital - CMSC 1102
600 N. Wolfe Street
Baltimore, MD 21287-3923
Phone:  410-955-5883
Fax:    410-955-0229
e-mail: Hlederm1 at jhem.jhmi.edu


----- Original Message -----
From: Christine Seroogy <CMSEROOGY at wisc.edu>
Date: Wednesday, March 22, 2006 6:57 pm
Subject: [PAGID] IFN-gamma

> Hi,
> 
> I would like to hear people's opinions about the use of IFN-g in 
> the  
> setting of acute infection in CGD patients.  We have a newly  
> diagnosed 2.5 year boy who presented with aspergillus pneumonia.  
> His  
> DHR looks like gp91 but Mom's DHR was completely normal and 
> molecular  
> diagnosis is pending.  He clinically has been very stable despite 
> a  
> terrible looking lung CT (one month into therapy).  We have 
> confirmed  
> aspergillus and now have sensitivities and will be treating him 
> with  
> voriconazole and caspofungin IV.
> 
> He has never been on IFN-g and the opinions I have received thus 
> far  
> are mixed.
> 
> Thanks for any input.  Chris
> 
>