[PAGID] IFN-gamma

[tamemi]

I would strongly recommend using IFN-g as adjuvant therapy to antifungal
medications in this setting. I had a similar CGD patient with an invasive
pulmonary infection (high grade fever, tachypnia and a terrible looking lung
on CT) most likely due to Candida. Only after 6 weeks into the course of
antifungal and 2 weeks into IFN-g therapy fever subsided. It seems that it
does work in acute infections as well. I would also keep this patient on
IFN-g therapy after resolution of his acute infection   

Salem Al-Tamemi, MD.FAAP.FRCPC. 
Consultant 
Clinical Immunology & Allergy 
Child Health Department
Sultan Qaboos University Hospital 
Muscat, Oman 


-----Original Message-----
From: pagid-bounces at clinimmsoc.org [mailto:pagid-bounces at clinimmsoc.org] On
Behalf Of Christine Seroogy
Sent: Thursday, March 23, 2006 3:58 AM
To: pagid at clinimmsoc.org
Subject: [PAGID] IFN-gamma

Hi,

I would like to hear people's opinions about the use of IFN-g in the  
setting of acute infection in CGD patients.  We have a newly  
diagnosed 2.5 year boy who presented with aspergillus pneumonia.  His  
DHR looks like gp91 but Mom's DHR was completely normal and molecular  
diagnosis is pending.  He clinically has been very stable despite a  
terrible looking lung CT (one month into therapy).  We have confirmed  
aspergillus and now have sensitivities and will be treating him with  
voriconazole and caspofungin IV.

He has never been on IFN-g and the opinions I have received thus far  
are mixed.

Thanks for any input.  Chris