[PAGID] IVIG and aseptic meningitis

[Chris Seroogy]

Dear Colleagues,

I have a question about management of aseptic meningitis and IVIG.

We have a 5 y/o with chemotherapy-induced immunodeficiency who meets
criteria for immunoglobulin replacement.  He just had his first infusion
(400mg/kg gammagard S/D) which went well, but 48 hours later developed
severe headache and stiff neck.  I did not evaluate him, but the heme/onc
colleagues felt he had aseptic meningitis and this resolved with pain
management.

My question is what has worked for individuals to prevent/prophylaxis this
side effect?  He needs the product and I am told subcutaneous is not an
option since he will pull out the tubing and it would be too much of a time
commitment for the family.  Thank you for any input!  Regards, Chris