[PAGID] IVIG and aseptic meningitis

[Charles.Kirkpatrick at UCHSC.edu]

It is unfortunate that SQ IgG is not an option.  I have 5 patients with
antibody deficiencies who has severe post infusion headache after IV
IgG.  All have done very well on SQ IgG.  No headaches. No infections.
One patient infuses only once a week.  Maybe that would not be too much
work for the family.  

The other thing that may help is to infuse some saline at the end of the
IV IgG infusion.  

Charles Kirkpatrick, M.D.

-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Chris Seroogy
Sent: Wednesday, December 05, 2007 8:21 AM
To: pagid at list.clinimmsoc.org
Subject: [PAGID] IVIG and aseptic meningitis

Dear Colleagues,

I have a question about management of aseptic meningitis and IVIG.

We have a 5 y/o with chemotherapy-induced immunodeficiency who meets
criteria for immunoglobulin replacement.  He just had his first infusion
(400mg/kg gammagard S/D) which went well, but 48 hours later developed
severe headache and stiff neck.  I did not evaluate him, but the
heme/onc
colleagues felt he had aseptic meningitis and this resolved with pain
management.

My question is what has worked for individuals to prevent/prophylaxis
this
side effect?  He needs the product and I am told subcutaneous is not an
option since he will pull out the tubing and it would be too much of a
time
commitment for the family.  Thank you for any input!  Regards, Chris