[PAGID] CGD pregnancy

[Antonio Condino]

Hi Jordan

This is an unusual situation, but we have to start getting prepared to manage it
more frequently from now on, since our CGD patients are living better and
longer.

My sugestion is to focus on the mother health and keep with the same
prophilaxis. You know we do have other drug alternatives, but they all
represent a potential risk during pregnancy.

So the mother shoud be aware about that and make a decision.

All best wishes

Condino

-- 
Antonio Condino MD PhD 
Associate Professor
Department of Immunology
Institute of Biomedical Sciences
University of Sao Paulo
1730 Lineu Prestes Avenue 1730
Sao Paulo - SP. ZIP 05508-900.
Brazil
Tel 55 11 3091-7387
Fax 55 11 3091-7224



Citando Jordan Orange <orange at mail.med.upenn.edu>:


> Dear Colleagues,

> 

> I currently have a 27yo patient with autosomal recessive CGD who  

> would like become pregnant.

> 

> Does anyone have experience with this situation?

> 

> I have many concerns.

> 

> One small, but practical concern is that both TMP/SMX and  

> itraconazole are pregnancy category C.  If she were to become  

> pregnant, is there an acceptable alternative prophylactic regimen  

> which would be safer for the fetus?  Alternatively, should TMP/SMX  

> and itraconazole be continued?

> 

> This patient and her family have an appropriate fear of CGD, as her  

> younger sister died of fungal pneumonia 3 years ago.

> 

> Thank you for reading this message and for any advice you might be  

> able to offer.

> 

> Best regards,

> 

> Jordan

> 

> Jordan Orange MD/PhD

> Assistant Professor of Pediatrics

> University of Pennsylvania School of Medicine

> Children's Hospital of Philadelphia, Division of Immunology

> 3615 Civic Center Blvd,  ARC-1016H

> Philadelphia, PA 19104

> (Voice) 267-426-5622

> (Fax) 267-426-5727

> www.orangelab.org

> 

> 

> 

> 

> 



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