[PAGID] CGD pregnancy

[Luigi Notarangelo]

Years back, I had a similar case (mine was a p67 deficiency). In the absence
of anti-fungal prophylaxis, she developed severe aspergillosis during
pregnancy.
If that counts...

Gigi


On 2/6/08 12:31 AM, "Jordan Orange" <orange at mail.med.upenn.edu> wrote:


>  Dear Colleagues,

> 

> I currently have a 27yo patient with autosomal recessive CGD who would like

> become pregnant.

> 

> Does anyone have experience with this situation?

> 

> I have many concerns.  

> 

> One small, but practical concern is that both TMP/SMX and itraconazole are

> pregnancy category C.  If she were to become pregnant, is there an acceptable

> alternative prophylactic regimen which would be safer for the fetus?

>  Alternatively, should TMP/SMX and itraconazole be continued?

> 

> This patient and her family have an appropriate fear of CGD, as her younger

> sister died of fungal pneumonia 3 years ago.

> 

> Thank you for reading this message and for any advice you might be able to

> offer.

> 

> Best regards,

> 

> Jordan

> 

>  

> Jordan Orange MD/PhD

> Assistant Professor of Pediatrics

> University of Pennsylvania School of Medicine

> Children's Hospital of Philadelphia, Division of Immunology

> 3615 Civic Center Blvd,  ARC-1016H

> Philadelphia, PA 19104

> (Voice) 267-426-5622

> (Fax) 267-426-5727

> www.orangelab.org

> 

> 

> 

>  

> 

> 



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