[PAGID] Attached umbilical cord in 8 week old

[Berger, Melvin]

According to the Chapter by Sergio Rosenzweig et al in the 5th Ed of Stiehm's textbook (pg 633), this pattern has been seen in E-selectin deficiency. 

In the paper by Novack, et al, (Am J Dis Child 142: 220-3, 1988) normal babies had separations as late as 45 days, but 56 is stretching it. 

Mel Berger

-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Chris Seroogy
Sent: Wednesday, March 05, 2008 2:53 PM
To: pagid at list.clinimmsoc.org
Subject: [PAGID] Attached umbilical cord in 8 week old

Dear Colleagues:

I saw an 8 week old FT male in clinic this week with a solidly attached
umbilical stump.  He has had two hospitalizations for pneumonia.  One at 3
weeks (documented RSV) and the second bilateral infiltrates responsive to
antibiotics 2 weeks ago with documented resolution.  His weight is at the
10%ile and down from birth (25-50%ile).  Normal immunoglobulins, normal T, B
and NK cell numbers.  Initially with the second hospitalization he was
slightly neutropenic (ANC 1000) and this has normalized.  He has never had a
leukocytosis on numerous CBCs.  His flow for CD18 and CD11b is normal.  I
intend to send DHR.  It seems he needs more PMN functional studies, but I am
perplexed by the lack of leukocytosis.  I welcome any thoughts.  Regards,
Chris


Chris Seroogy, M.D.

Assistant Professor

Dept. of Pediatrics

Mail:  H4/474 CSC, Mailstop 4108

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Madison, WI  53792

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