[PAGID] Yellow fever vaccine in SDS?

[Church, Joseph]

SDS patients often have selective antibody deficiency.  If there is
time, I suggest you check antibody titers to previous vaccines.  If
these are normal you would have more evidence that the YF vaccine should
be tolerated.

 

Joe Church

Childrens Hospital Los Angeles

 

-----Original Message-----
From: pagid-bounces at list.clinimmsoc.org
[mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Dr. Esther de
Vries
Sent: Friday, August 06, 2010 1:09 AM
To: pagid at list.clinimmsoc.org
Subject: [PAGID] Yellow fever vaccine in SDS?

 

Dear all, I have a 10-year-old SDS patient who is clinically doing very
well. He has relapsing mild granulocytopenia, stable bone marrow smears,
and had some bouts of unexplained rheumatoid-like arthritis a few years
ago. Because he is doing so well, the parents want to visit southern
coastal Kenia with him, an area where yellow fever does not occur very
often. He received MMR without problems in the past. The parents prefer
to give him a yellow fever vaccine if possible, but the doctor at the
tropical travel service is reluctant, and wants my permission. Since
this is a live attenuated vaccine, and abnormalities in T-lymphocyte
function in SDS patients have been published, I cannot give a 100%
guarantee of safety. Does anyone have experience with this vaccine in
SDS? Thanks! Esther de Vries, 's-Hertogenbosch, the Netherlands



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