[CIS-PAGID] Ivasive pneumococcal disease.

[Jack Bleesing]

Does normal TLR function, as measured by IBT labs or elsewhere, mean
that TLR-related disorders (e.g. IRAK4 defects) are for sure ruled out?

 
Does (did) the CRP go up (appropriately) with infections?
 
Regards,
 
JB
 
 
---------------------------------------------------------------------------
Jack J.H. Bleesing, M.D., Ph.D.
Associate Professor of Pediatrics
Cincinnati Children's Hospital Medical Center
Division of Bone Marrow Transplantation and Immune Deficiency
3333 Burnet Avenue, MLC 7015
Cincinnati, OH 45229
513-636-4266 (phone)
513-636-3549 (fax)


>>> "Church, Joseph" <JChurch at chla.usc.edu> 3/16/2011 1:48 PM >>>


Colleagues:
 
I have evaluated a 4yo boy who had pneumococcal pneumonia + empyema at
2.5yo.
 
His fraternal twin died at 6mo from pneumococcal meningitis.
 
Normal labs have included:
-          CBCs
-          IgG, A, M, E
-          Tetanus, Hib, pneumococcal vaccine responses (including
persistently +19/23 serotypes following Pneumovax)
-          CH50
-          AH50
-          T, B numbers
-          Mitogen and antigen LPAs
-          HIV PCR
-          Mannose binding lectin 
-          TLR function (measured at IBT Labs).
 
What am I missing?
 
Joe Church
Clinical Immunology and Allergy
Children’s Hospital Los Angeles
 
 


---------------------------------------------------------------------
CONFIDENTIALITY NOTICE: This e-mail message, including any attachments,

is for the sole use of the intended recipient(s) and may contain
confidential
or legally privileged information. Any unauthorized review, use,
disclosure
or distribution is prohibited. If you are not the intended recipient,
please
contact the sender by reply e-mail and destroy all copies of this
original message. 
---------------------------------------------------------------------
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20110316/3ae50b53/attachment.htm>