[CIS-PAGID] CVID Pt wheezes 12h after Hizentra

[Saxon, Andy M.D.]

What the heck are you doing taking care of 57 yo ladies down at Children's Joe?

I have not seen it but Marc Riedl and others have far more experience with the SQ than I do. I'd get spirometry before her infusion and then again when see is wheezing to see what you got there objectively

Andy Saxon
UCLA

________________________________
From: pagid-bounces at list.clinimmsoc.org [mailto:pagid-bounces at list.clinimmsoc.org] On Behalf Of Church, Joseph
Sent: Friday, April 15, 2011 5:49 PM
To: pagid at list.clinimmsoc.org
Subject: [CIS-PAGID] CVID Pt wheezes 12h after Hizentra

Colleagues:

I recently started to follow a 57yo lady with CVID.  She has lots of other complaints (fatigue, arthralgias, thyroid disease, migraines, mitral valve prolapse...).

She had significant reactions following Vivaglobin: fatigue, nausea, hives.

She is receiving Hizentra.  Approximately 12h after each infusion she complains of wheezing.  This is responsive to Xopenex and not of a severity to consider discontinuing the infusions.

Has anyone seen this in patients following SCIG?

IgG anti-IgA is pending.

Thank you for your thoughts.

Joe Church
Children's Hospital Los Angeles

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