[CIS-PAGID] question about TLR defects

[Nacho Gonzalez]

Dear Jason,

As colleagues from Necker Hospital could confirm, TLR defects show
*delayed*but not absent CRP elevation as well as fever (this clinical
clue is also
present but delayed). I mean CRP and temperature may be normal at the onset,
but within 24-48 hours they commonly show Tª above 38 degrees and elevated
CRP

Regards,

Luis Ignacio Gonzalez Granado
Immunodeficiencies Unit.
Hospital 12 octubre. Madrid. Spain

2011/6/6 <raas0027 at umn.edu>


>

> Good morning all,

>

> Two year-old with 20-month history of recurrent otitis media and

> bronchitis/pneumonia historically treated as an outpatient.

>

> Basic immunologic evaluation unremarkable(cbc, Ig's, flow cytometry,

> complement, MBL, etc.)

>

> I suspect GERD and emerging atopy significant contributing factors.

>

> Currently ospitalized with pneumonia with pleural effusion.

>

>

> This patient becomes febrile and CRP is quite elevated in the present case.

> FOR THIS REASON I DOUBT A TLR DEFECT is on the differential diagnosis.

>

> Agree or disagree?

>

>

>

> Thanks for your thoughts.

>

> -Jason

>

>

> --

> Jason Raasch, MD

>

> Midwest Immunology Clinic

> 15700 37th Ave N

> Suite 110

> Plymouth, MN 55446

>

> (Phone) 763.577.0008

> (FAX)   763.5770192

>

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