[CIS-PAGID] quick question

[Routes, John]

great---will check out these refs
thanks

John M. Routes, MD
Chief, Section of Allergy and Clinical Immunology
Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics
Department of Pediatrics
Children's Hospital of Wisconsin
Medical College of Wisconsin
9000 W. Wisconsin Ave.
Milwaukee, WI  53226-4874

Phone: 414-456-4802; 414-266-6997
Fax: 414-456-6487 (Clinical)
Fax: 414-456-6323 (Laboratory)
Email: jroutes at mcw.edu




________________________________
From: Javier Chinen <chinej20 at hotmail.com>
Reply-To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Date: Thu, 18 Aug 2011 08:01:11 -0500
To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
Subject: Re: [CIS-PAGID] quick question


Those are excellent references. I believe it is important to consider the trough IgG level of the patients to assess the specific antigen titers in these data. In the Gamunex paper from Sep 2010, the avg trough IgG level was about 1 g.
Javier

________________________________
Date: Wed, 17 Aug 2011 22:53:05 -0400
From: Melvin.Berger at UHhospitals.org
To: pagid at list.clinimmsoc.org
Subject: Re: [CIS-PAGID] quick question

[CIS-PAGID] quick question
Titers against the standard antigens may be available in the "Product Monographs" produced by the companies and in some publications. They are provided in Table 11 on page 30 of the Privigen Monograph, also in Wasserman et al. Eur J Pharm Sci 37: 272-278 (2009). Titers against bacterial polysaccharides in patients receiving IV and SC Gamunex are published in Wasserman et al, Clin Exp Immunol 2011 (doi: 10.111/j.1365.2249.2010.04195.x). Most Biological License Applications contain info on titers against two proteins, two viruses and at least two types of polysaccharides, which you can try to get by looking up each product on the FDA website. They may be in the prescribng information for individual products as well.

I know of no data on antibody titers against broad ranges of antigens for any of the products.

Melvin Berger, M.D., Ph.D.
Adjunct Professor of Pediatrics and Pathology
Case Western Reserve University
Cleveland, OH 44106

________________________________
From: pagid-bounces at list.clinimmsoc.org on behalf of Routes, John
Sent: Tue 8/16/2011 12:24 PM
To: pagid at list.clinimmsoc.org
Subject: [CIS-PAGID] quick question

I have a quick question--Is there a way to find out specific Ab titers to
different Ags in commercially available IVIG or SCIG?
thanks

John M. Routes, MD
Chief, Section of Allergy and Clinical Immunology
Professor of Pediatrics, Medicine, Microbiology and Molecular Genetics
Department of Pediatrics
Children's Hospital of Wisconsin
Medical College of Wisconsin
9000 W. Wisconsin Ave.
Milwaukee, WI  53226-4874

Phone: 414-456-4802; 414-266-6997
Fax: 414-456-6487 (Clinical)
Fax: 414-456-6323 (Laboratory)
Email: jroutes at mcw.edu