[CIS PIDD] Low CH50

[Santhosh Kumar/FS/VCU]

Dear All,

I have 6 y/o F who was referred to me by my ID colleague for recurrent febrile episodes since starting school. She has not had any major infections which needed hospitalization. Most of her febrile episodes were thought to be virally related. Her immune work up is normal except for low CH50 levels (repeated x 2- 12 and 15U/ml). His other classic pathway complements are normal (c2, c3, c4, c6, c7, c8,c9). AH50 is pending. I had heard of falsely low CH50 levels in past depending on the assay used. My question is:

Is this a false low CH50 level and if so is there a  better assay which can be used to confirm


Thank you,

Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology
Medical college of Virginia
Ph-  804-628-1605
Fax-804-828-1751
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