[CIS PIDD] Low CH50

[Anita Gewurz]

Dear Santhosh,

Regarding complement testing for in vitro consumption and other assays, contact:

Patricia Giclas PhD, GiclasP at NJHealth.org
Director, Complement Laboratory
Professor, Pediatrics Dept,  Allergy and Immunology Division
National Jewish Medical and Research Center
1400 Jackson St., Denver, CO 80206  Office: M013f, BB Building
TEL 303-398-1217
FAX 303-270-2128
www.njc.org/research/clinical-labs/about/learn/diaglab/complement.aspx<http://www.njc.org/research/clinical-labs/about/learn/diaglab/complement.aspx>

Your DDx should include periodic fever syndromes.

Anita Gewurz MD
Department of Immunology/Microbiology
Rush University Medical Center
Chicago IL 60612
Tel (312) 942-6296
Fax (312) 563-2201

From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] on behalf of Santhosh Kumar/FS/VCU [skumar at vcu.edu]
Sent: Wednesday, July 11, 2012 8:58 AM
To: pagid at list.clinimmsoc.org
Subject: [CIS PIDD] Low CH50

Dear All,

I have 6 y/o F who was referred to me by my ID colleague for recurrent febrile episodes since starting school. She has not had any major infections which needed hospitalization. Most of her febrile episodes were thought to be virally related. Her immune work up is normal except for low CH50 levels (repeated x 2- 12 and 15U/ml). His other classic pathway complements are normal (c2, c3, c4, c6, c7, c8,c9). AH50 is pending. I had heard of falsely low CH50 levels in past depending on the assay used. My question is:

Is this a false low CH50 level and if so is there a  better assay which can be used to confirm


Thank you,

Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology
Medical college of Virginia
Ph-  804-628-1605
Fax-804-828-1751
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://seven.pairlist.net/mailman/private/pagid/attachments/20120711/c90564e1/attachment.html>