[CIS PIDD] Low CH50

[Santhosh Kumar/FS/VCU]

Thank you all for the information.

She has a normal IgD and CRP level so far and she has been afebrile for a while now. She never had a consistent pattern to her fevers and not all of her febrile episodes were documented. If the febrile episodes persist, we will proceed with further workup for periodic fevers.

Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology
Ph-  804-628-1605
Fax-804-828-1751



-----pagid-bounces at list.clinimmsoc.org wrote: ----- 
To: "pagid at list.clinimmsoc.org" <pagid at list.clinimmsoc.org>
From: Anita Gewurz 
Sent by: pagid-bounces at list.clinimmsoc.org
Date: 07/11/2012 10:31AM
Subject: Re: [CIS PIDD] Low CH50


Dear Santhosh, 


Regarding complement testing for in vitro consumption and other assays, contact:


Patricia Giclas PhD, GiclasP at NJHealth.org
Director, Complement Laboratory
Professor, Pediatrics Dept,  Allergy and Immunology Division
National Jewish Medical and Research Center
1400 Jackson St., Denver, CO 80206  Office: M013f, BB Building
TEL 303-398-1217
FAX 303-270-2128
www.njc.org/research/clinical-labs/about/learn/diaglab/complement.aspx


Your DDx should include periodic fever syndromes.  


Anita Gewurz MD
Department of Immunology/Microbiology
Rush University Medical Center
Chicago IL 60612
Tel (312) 942-6296
Fax (312) 563-2201


From: pagid-bounces at list.clinimmsoc.org [pagid-bounces at list.clinimmsoc.org] on behalf of Santhosh Kumar/FS/VCU [skumar at vcu.edu]
Sent: Wednesday, July 11, 2012 8:58 AM
To: pagid at list.clinimmsoc.org
Subject: [CIS PIDD] Low CH50


Dear All,
 
I have 6 y/o F who was referred to me by my ID colleague for recurrent febrile episodes since starting school. She has not had any major infections which needed hospitalization. Most of her febrile episodes were thought to be virally related. Her immune work up is normal except for low CH50 levels (repeated x 2- 12 and 15U/ml). His other classic pathway complements are normal (c2, c3, c4, c6, c7, c8,c9). AH50 is pending. I had heard of falsely low CH50 levels in past depending on the assay used. My question is:
 
Is this a false low CH50 level and if so is there a  better assay which can be used to confirm
 
 
Thank you,
 
Santhosh Kumar, MD
Assistant Professor,
Allergy & Immunology
Medical college of Virginia
Ph-  804-628-1605
Fax-804-828-1751
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