[CIS PIDD] Low CH50

[Anete S Grumach]

Dear Santhosh,

Low CH50 levels could be related to the sample collection. Considering that
most of complement proteins are termolabil, activation of classical pathway
could occurr and it would generate low levels.
Partial deficiency of C4 (usually C4B deficiency) is associated to
recurrent infections and C4 levels are reduced.
The consumption of complement components could lead to low CH50 levels and
the evaluation of split components of Complement system as C3d could be
helpful. Most of inherited complement deficiencies present with
undetectable CH50.
Lectin pathway is not screened by CH50 or AP50.

Best regards

Anete

2012/7/11 Santhosh Kumar/FS/VCU <skumar at vcu.edu>


> Dear All,

>

> I have 6 y/o F who was referred to me by my ID colleague for recurrent

> febrile episodes since starting school. She has not had any major

> infections which needed hospitalization. Most of her febrile episodes were

> thought to be virally related. Her immune work up is normal except for low

> CH50 levels (repeated x 2- 12 and 15U/ml). His other classic pathway

> complements are normal (c2, c3, c4, c6, c7, c8,c9). AH50 is pending. I had

> heard of falsely low CH50 levels in past depending on the assay used. My

> question is:

>

> Is this a false low CH50 level and if so is there a  better assay which

> can be used to confirm

>

>

> Thank you,

>

> Santhosh Kumar, MD

> Assistant Professor,

> Allergy & Immunology

> Medical college of Virginia

> Ph-  804-628-1605

> Fax-804-828-1751

>

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