[CIS PIDD] [cis-pidd] Neutropenia and low interferon gamma production

[Church, Joseph]

What assay was done for INF-g production?

Were immunoglobulin levels normal?

Joe Church
Children's Hospital Los Angeles

From: Wiens, Lynn A MD [mailto:lawiens at saintfrancis.com]
Sent: Thursday, September 04, 2014 7:01 AM
To: CIS-PIDD
Subject: [cis-pidd] Neutropenia and low interferon gamma production


I am taking care of a 2 yo male with idiopathic neutropenia doing well on Neupogen.  As part of his work-up, I obtained T-cell function and PHA did upregulate CD 69 but there was no interferon gamma production.  In vitro proliferation to tetanus toxoid, viral mixture, candida was low.  Response to PWM; staph superantigen was normal.

My question is what additional genetic testing is indicated in a boy doing well with neupogen; no additional infections since starting.

Lynn A. Wiens, MD

Warren Clinic

6160 South Yale Avenue  Tulsa, OK 74136

Specializing in the care of Allergy, Asthma, Sinus disease, and Chronic Infections

http://tulsaallergynews.com

Office: 918-495-2636

Cell: 918-550-1200

[Picture (Device Independent Bitmap)]

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