[CIS PIDD] [cis-pidd] Neutropenia and low interferon gamma production

[Kumar, Ashish]

Has he had any serious pyogenic infections or was the neutropenia discovered on CBC? Most children of this age will have benign autoimmune neutropenia for which Neupogen is not really necessary. I am not sure what to make of all the other results in the context of a healthy child.

Ashish Kumar, MD, PhD
Cancer and Blood Diseases Institute
Division of Bone Marrow Transplantation and Immune Deficiency
Cincinnati Children's Hospital Medical Center
http://www.cincinnatichildrens.org/bio/k/ashish-kumar/
http://www.cincinnatichildrens.org/research/divisions/b/bone-marrow/labs/kumar/default/

From: Wiens, Lynn A MD [mailto:lawiens at saintfrancis.com]
Sent: Thursday, September 04, 2014 10:01 AM
To: CIS-PIDD
Subject: [cis-pidd] Neutropenia and low interferon gamma production


I am taking care of a 2 yo male with idiopathic neutropenia doing well on Neupogen.  As part of his work-up, I obtained T-cell function and PHA did upregulate CD 69 but there was no interferon gamma production.  In vitro proliferation to tetanus toxoid, viral mixture, candida was low.  Response to PWM; staph superantigen was normal.

My question is what additional genetic testing is indicated in a boy doing well with neupogen; no additional infections since starting.

Lynn A. Wiens, MD

Warren Clinic

6160 South Yale Avenue  Tulsa, OK 74136

Specializing in the care of Allergy, Asthma, Sinus disease, and Chronic Infections

http://tulsaallergynews.com

Office: 918-495-2636

Cell: 918-550-1200

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