[CIS PIDD] [cis-pidd] Low TRECs, nromal mitogens, progressive lymphopenia

[Cooper, Megan]

Hi Richard - it looks as if all the populations are dropping, I might consider ADA (somewhat delayed onset).

Megan

Megan A. Cooper, MD, PhD
Assistant Professor, Department of Pediatrics
Division of Rheumatology
Washington University School of Medicine
Cooper_m at kids.wustl.edu<mailto:Cooper_m at kids.wustl.edu>
Lab website: http://research.peds.wustl.edu/Default.aspx?alias=research.peds.wustl.edu/Labs/Cooper_M

On Jan 6, 2015, at 7:47 PM, Richard Wasserman <drrichwasserman at gmail.com<mailto:drrichwasserman at gmail.com>> wrote:


Please give me your thoughts on the best next steps for this six month old male who is thriving and has never been infected.

July 3, 2014 - Date of Birth

July 4, 2014, July 11, 2014 - Very Low TRECs

July 25, 2014

Absolute Lymphocytes L 3428 (cells/uL) 3400-7600

Absolute Cd3+ Cells L 1845 (cells/uL) 2500-5500

Absolute Cd4+ Cells L 1435 (cells/uL) 1600-4000

Absolute Cd8+ Cells L 389 (cells/uL) 680-1700

Absolute Nk Cells (cd16+cd56+cells) 735 (cells/uL) 170-1100

Absolute Cd19+ Cells L 828 (cells/uL) 300-2000

Absolute Cd3+Cd4+Cd45RA+Cd62L+ 1260 (cells/uL) 1200-3600

Absolute Cd3+Cd4+Cd45RO+ 232 (cells/uL) 60-900

Absolute Cd3+Cd8+Cd45RA+Cd62L+ 363 (cells/uL) 3800-1300

Absolute Cd3+Cd4+Cd45RO+ 18 (cells/uL) 30-330

PHA, PWM and ConA stimulation was normal

January 5, 2015

Absolute Lymphocytes L 1559 (cells/uL) 4000-13500

Absolute Cd3+ Cells L 754 (cells/uL) 2160-5540

Absolute Cd4+ Cells L 547 (cells/uL) 1390-4080

Absolute Cd8+ Cells L 222 (cells/uL) 600-1490

Absolute Nk Cells (cd16+cd56+cells) 184 (cells/uL) 160-930

Absolute Cd19+ Cells L 519 (cells/uL) 740-2560

 Thanks,
Richard
--
Richard L. Wasserman, MD, PhD
DallasAllergyImmunology
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
Cell (214) 697-7211

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