[CIS PIDD] [cis-pidd] live vaccines in Digeorge population

[Junker, Anne]

We consider life infection experiences to be the best test of immune function.  Unless there has been a significant history of infections we don't repeat T cell studies. Ig levels and maintenance of specific antibody to infant vaccines affirm T cell competence in these children.  

Anne Junker, MD
Associate Professor
University of British Columbia
Vancouver, BC
________________________________________
From: Anastasiya Ashurova [ana.ashurova at gmail.com]
Sent: Thursday, April 23, 2015 12:57 PM
To: CIS-PIDD
Subject: [cis-pidd] live vaccines in Digeorge population

Hi
We are following a 15 month old DiGeorge baby found to have a 22q11 deletion at birth.  We are in the process of clearing her for the MMR vaccine.  Workup has shown normal T/B/NK flow cytometry, protective titers to Tetanus (1.86), Hib (2.39) with 13 of 13 protective pneumococcal titers.  She had a normal proliferative response to PHA, PW, and Con A but did not proliferate to tetanus and although she had a response to candida, it was not robust.   Would you vaccinate this patient with a live vaccines?

Thank you,
Anastasiya Kleva
Fellow, Division of Allergy and Immunology
Cohen’s Children’s Medical Center

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