[CIS PIDD] [cis-pidd] live vaccines in Digeorge population

[Fani Ladomenou]

Yes we would give live vaccines in this case

Fani Ladomenou
Paediatric Immunology Fellow
Great Ormond Street Hospital
London
UK
Fani.Ladomenou at gosh.nhs.uk

Sent from my iPhone

> On 23 Apr 2015, at 20:57, Anastasiya Ashurova <ana.ashurova at gmail.com> wrote:
> 
> Hi
> 
> We are following a 15 month old DiGeorge baby found to have a 22q11 deletion at birth.  We are in the process of clearing her for the MMR vaccine.  Workup has shown normal T/B/NK flow cytometry, protective titers to Tetanus (1.86), Hib (2.39) with 13 of 13 protective pneumococcal titers.  She had a normal proliferative response to PHA, PW, and Con A but did not proliferate to tetanus and although she had a response to candida, it was not robust.   Would you vaccinate this patient with a live vaccines?  
> 
>  
> 
> Thank you,
> 
> Anastasiya Kleva
> 
> Fellow, Division of Allergy and Immunology
> 
> Cohen’s Children’s Medical Center
> 
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