[CIS PIDD] [cis-pidd] adult patient with auto-immunity and recurrent airway infections

[CIS-PIDD]

If PID, consider APDS (or CTLA-4 and STAT3 GOF - because of the "MS",
STAT1 GOF). Hyper- may precede hypogamma in these conditions.


Beste Grüße 

Prof. Dr. Stephan Ehl
Medizinischer Direktor

UNIVERSITÄTSKLINIKUM FREIBURG
CCI - Center for Chronic Immunodeficiency

Breisacher Str. 117 - 2. OG, 79106 Freiburg i. Brsg., Germany
phone: +49(0)761.270-77300
Sekretariat +49(0)761.270-77550  fax +49(0)761.270-77600
e-mail: stephan.ehl at uniklinik-freiburg.de





Am 20.10.15 11:32 schrieb "CIS-PIDD" unter <cis-pidd at lists.clinimmsoc.org>:

>A 63-year-old woman who has been diagnosed with Sjögren syndrome and
>multiple sclerosis was referred to me because of recurrent upper and
>lower airway infections since 10 years, chronic cough, and
>bronchiectasis with the question whether she has immunodeficiency. She
>has not been using any immunosuppressive medication for many years, nor
>has she ever been treated with IVIG because of her MS.
>Her lab shows auto-antibodies, hypergammaglobulinemia with IgG2
>deficiency, and partial polysaccharide antibody deficiency (details in
>the attachment, Ig's in g/l).
>Should we consider her to be a patient with primarily auto-immune
>disease, or a patient with a form of primary immunodeficiency, and if
>so, which?
>Your suggestions are welcome!
>Esther de Vries, 's-Hertogenbosch/Tilburg, the Netherlands
>---
>You are currently subscribed to cis-pidd as:
>stephan.ehl at uniklinik-freiburg.de.
>To unsubscribe click here:
>http://cts.dundee.net/u?id=96396905.c7f19e2786458b3d17c11bb0a69a0a7f&n=T&l
>=cis-pidd&o=3222544
>or send a blank email to
>leave-3222544-96396905.c7f19e2786458b3d17c11bb0a69a0a7f at lyris.dundee.net


---
You are currently subscribed to cis-pidd as: pagid at list.clinimmsoc.org.
To unsubscribe click here: http://cts.dundee.net/u?id=96396833.5a9591ccd1e327fe6bc4d1543298c482&n=T&l=cis-pidd&o=3222558
or send a blank email to leave-3222558-96396833.5a9591ccd1e327fe6bc4d1543298c482 at lyris.dundee.net