[CIS PIDD] [cis-pidd] IVIG or SCIG

[CIS-PIDD]

Thank you Richard.  I agree that SCIG or IGHy would be preferable, but your suggestion of dividing the IV doses makes sense.  JC

From: cis-pidd at lyris.dundee.net [mailto:cis-pidd at lyris.dundee.net] On Behalf Of CIS-PIDD
Sent: Tuesday, June 06, 2017 10:33 AM
To: CIS-PIDD
Subject: Re: [cis-pidd] IVIG or SCIG (EXTERNAL EMAIL)

Joe,
I don't have experience with tamoxifen and IG but, as you know, the IVIG thrombosis risk is related to factor 11a which is now low to absent from most/all products. You can reduce the risk by treating every two weeks so that the dose is low and with a long infusion time. I would still prefer IGSC or IGHy.
Richard Wasserman
Dallas

On Tue, Jun 6, 2017 at 10:53 AM, CIS-PIDD <cis-pidd at lists.clinimmsoc.org<mailto:cis-pidd at lists.clinimmsoc.org>> wrote:
Colleagues:

I consulted on a 46yo F who requires immunoglobulin replacement therapy.  She is s/p bilateral mastectomy for breast cancer and on tamoxifen as maintenance.

Tamoxifen “slightly” increases the risk for DVTs etc.

However, the patient would prefer IVIG over SCIG.

Does anyone have experience with the combination of IVIG + tamoxifen and the risk of thrombotic events?

Thank you for your help.

Joe Church
Children’s Hospital Los Angeles



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--
Richard L. Wasserman, MD, PhD
Allergy Partners of North Texas
7777 Forest Lane, Suite B-332
Dallas, Texas 75230
Office (972) 566-7788
Fax (972) 566-8837
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